אנזים שעוצר נזק MS?(קליניקת מאיו) ../images/Emo22.gif
חדשות טריות. צר לי, אך באנגלית...: Mayo Clinic researchers discover enzyme has potential to stop multiple sclerosis tissue damage Mayo Clinic researchers have found a new clue in the search for a way to stop the demyelination that occurs in multiple sclerosis (MS). They found a dramatic increase in a newly discovered degradative enzyme, myelencephalon-specific protease (MSP), in demyelinated tissue, indicating that inhibiting this enzyme could potentially block the process of tissue damage. This is a first-ever finding of the link between MSP and the debilitation that patients experience in MS. This study will be published in the June 2002 issue of Brain. Dr. Isobel Scarisbrick and colleagues discovered MSP in 1997. They cloned MSP and developed probes and other tools to work with the enzyme and attempt to determine its role in demyelination. In the researchers´ investigation of mouse and human MS tissue, they discovered MSP´s dramatic increase in inflammatory cells in actively demyelinating human MS lesions. MSP is a multifunctional enzyme, facilitating entry of inflammatory cells into the brain and also contributing to tissue destruction when overexpressed. It also may harm processes of the oligodendroglia, cells found in the central nervous system that form the myelin sheath protecting the axon, a component of nerve cells. When functioning normally, however, MSP contributes to proper oligodendroglia function. Source: www.sciencedaily.com
חדשות טריות. צר לי, אך באנגלית...: Mayo Clinic researchers discover enzyme has potential to stop multiple sclerosis tissue damage Mayo Clinic researchers have found a new clue in the search for a way to stop the demyelination that occurs in multiple sclerosis (MS). They found a dramatic increase in a newly discovered degradative enzyme, myelencephalon-specific protease (MSP), in demyelinated tissue, indicating that inhibiting this enzyme could potentially block the process of tissue damage. This is a first-ever finding of the link between MSP and the debilitation that patients experience in MS. This study will be published in the June 2002 issue of Brain. Dr. Isobel Scarisbrick and colleagues discovered MSP in 1997. They cloned MSP and developed probes and other tools to work with the enzyme and attempt to determine its role in demyelination. In the researchers´ investigation of mouse and human MS tissue, they discovered MSP´s dramatic increase in inflammatory cells in actively demyelinating human MS lesions. MSP is a multifunctional enzyme, facilitating entry of inflammatory cells into the brain and also contributing to tissue destruction when overexpressed. It also may harm processes of the oligodendroglia, cells found in the central nervous system that form the myelin sheath protecting the axon, a component of nerve cells. When functioning normally, however, MSP contributes to proper oligodendroglia function. Source: www.sciencedaily.com
