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But vitamin C is by no means the only nutrient that should be supplemented if the immune system is to develop and function effectively. Nutrients known to be effective in autism, vitamin B6 and DMG, have been shown in laboratory studies to enhance immune function. The minerals zinc and selenium, both implicated in many cases of autism, are critical in immune function. Nutrition is the single most important determinant of immune function, according to world authority R. K. Chandra, who specifically mentions zinc, selenium, iron, copper, vitamins A, C, E, B6, and folic acid.